Winning the Fight against Aging

Winning the Fight against Aging

Frailty is an end stage of aging, characterized by physical weakness, chronic inflammation, and lack of robustness in response to challenges. Frail individuals tend to spiral downward into organ failure and death in response to adverse circumstances, such as infection or injury, that less frail, younger individuals can survive. The question of how to reverse frailty is an important one; in principle, a good enough way of addressing the underlying causative mechanisms of aging would lead to improvement in patient outcomes. A number of the groups involved in development of first generation age-slowing and rejuvenating therapies are looking to frailty as a target for initial clinical trials.

Is NMN the best option for raising NAD+ levels?

Every cell needs NAD+ to keep our furnaces burning, but NAD+ generation in the body is a complex process, and there are multiple ways it can be achieved.

   Vitamin B3 (niacin), for instance, also is a precursor of NAD+ (only about half as powerful as NMN), but there are limitations to the safe consumption of Vitamin B3. In addition, there are many types of cells in which Vitamin B3 cannot boost NAD+ levels, among which are neurons (perhaps this is the reason why Vitamin B3 has rarely helped Parkinson’s patients), and skeletal muscle cells… both of critical importance.

   Complexity aside, the most recent developments in university laboratories have brought NMN into the limelight as being the most promising of the potential NAD+ precursors, due largely  to the ease and speed of absorption.[1]

   Previously it was thought that NMN had to be converted into another molecule before entering our cells, but that was proved to be false. [6] Furthermore, based on the great concentration of genes that encode NMN transport in the small intestine, it is prima facie evidence that NMN is the primary NAD+ precursor that your body derives from food.[8]

   While NMN does not raise blood NAD+ levels as high as some other precursors, higher blood NAD+ levels may simply be a sign of less efficient transport into the cells, where needed. For this same reason, there is a growing number of enthusiasts who do not take NMN sublingually. Not everything we need from our diet is meant to be absorbed directly into our bloodstream.

   The latest evidence indicates that the small intestinal microbiota play a role in the generation of NMN, as suggested by the scientists who discovered the transporter gene. [8] The current evidence suggests that NMN can just as effectively be swallowed and later absorbed in the small intestine.

   For several reasons, formulators studies at LIDTKE concluded that capsules would be the most accurate and easily administered method of NMN delivery. For those who prefer sublingual absorption, small capsules dissolve quicker under the tongue than tablets… and unlike scoops, capsules provide a consistent dosage time after time.

   While it is true that powder is less expensive than capsules, scoops have a large, unpredictable error rate, and only a wellequiped laboratory is capable of accurately measuring  milligrams. Furthermore, capsules avoid loss from spillage and contamination.

   LIDTKE looks forward to bringing you the latest research on NAD+, including further human clinical trials of NMN and useful dietary cofactors that enhance NMN benefits. Thank you for choosing LIDTKE!


[1] Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice

[2] Rewinding the Clock

[3] Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

[4] The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock

[5] The Circadian NAD+ Metabolism: Impact on Chromatin Remodeling and Aging

[6] The elusive NMN transporter is found

[7] Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

[8] Slc12a8 is a nicotinamide mononucleotide transporter