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NADH Precursor


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The Anti-Aging Potential of NMN

as a Precursor to NADH


   LIDTKE NMN (a Vitamin B3 derivative) readily converts to nicotinamide adenine dinucleotide (NADH), a powerful and essential molecule that is found in every cell of the body. NAD+ levels are at their peak when we are young, but they decline as we age, draining our energy and exposing us to nearly every age-related dysfunction.


In the 1990’s LIDTKE began providing prescription NAD+ to pharmacies. The medical potential of NAD+ was clear, particularly for problems of neurological decline. Unfortunately the technology did not yet exist to significantly boost NAD+ levels in our muscle and brain cells, where it was most needed. Hence, NAD+ never seemed to live up to its potential.


NMN works in an entirely new way. NMN is a precursor molecule that passes through our cell walls quite easily, where our cells can then manufacture and boost NAD+ levels. NMN may not be the first precursor molecule discovered, but it absorbs faster into a variety of bodily tissues than other NAD+ precursors. [2] More importantly, after many decades of research, NMN appears to be living up to the NAD+ promise.


   In well-conducted animal studies, NMN already has demonstrated remarkable improvements in:

 • physiological function [1]

 • lean body mass [1]

 • the ability of endothelial cells to form new blood vessels [2,3]

 • the conversion of food to usable energy [1]

 • the regulation of the sleep/wake cycle [4,5]


   NMN is found in our normal diet, it is true, in trace amounts (1 mg per kg of food), [6] However, the small amount found in food only helps to slow the decline of our NAD+ levels, and it is not nearly enough to boost NAD+ to youthful levels. Clearly, we need to supplement as we age. Coincidentally, a human clinical trial has confirmed the safety of NMN in much higher than common dietary amounts, [7] and optimal levels may still prove to be higher than currently being recommended.


[1] Long-term administration of [NMN]  Cell Metab. Dec 2017.

[2] Rewinding the Clock Harvard Medical School. Mar 2018.

[3] Nicotinamide mononucleotide (NMN) supplementation Redox Biol. Jun 2019.

[4] The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock (c) 2011

[5] The Circadian NAD+ Metabolism BioMed Research International 2016.

[6] The elusive NMN transporter is found Nature Metabolism. Jan 2019.

[7] Effect of oral administration of [NMN] in healthy Japanese men. Endocrine Journal. 2020.

Download the In-Depth Article:

   Understanding NAD: the Assimilation of Precursors, its Generation in vivo, and its Effects on Aging and Human Health


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